Alleviating Potential of <i>Zingiber officinale</i> and Cow Urine Distillate Co-administered with Levetiracetam in Epileptic Rats: A Pharmacokinetic and Pharmacodynamics Approach

Background: Epilepsy is a severe neurological condition that affects all ages of people. Complex pathways involved in pathogenesis make it complicated to treat; selected antiepileptic drug options are available for Epilepsy. There need an hour develop novel treatment approaches epilepsy with lesser side effects. This research aimed evaluate the alleviating role bio-enhancers co-administered levetiracetam pilocarpine-induced epilepsy. Methodology: Pilocarpine (250 mg/kg) was used rats. Levetiracetam (LEV) (140 administered Zingiber officinale Extract (ZOE) (15 mg/kg and 30 Cow Urine Distillate (CUD) (1.5 ml/kg 3 ml/kg). HPLC concentration blood. Serum nitrate, catalase, CRP, calcium level brain, behavioural markers rats were assessed compared Leviteracetam group only. Result Discussion: The present study showed combining ZOE CUD advantageous through substantial reduction (p < 0.05) serum CRP increased catalase 0.05), while reduced LEV alone. Combination also seizure behaviour duration bioavailability plasma brain when epileptic treated plus disease control. Conclusion: Utilization combination proven therapeutically effective model lower dose along reducing time potential